Superhydrophobic wearable flexible sensors possess significant application potential in detecting human behaviors within amphibious environments. However, under complex wetting conditions, the failure of the superhydrophobic coating poses a critical challenge, as it degrades the internal conductive network and leads to device malfunction. Herein, we present an all-weather amphibious e-textile (AWAE) with a micro-/nano-armored superhydrophobicity, achieved by integrating an MXene–chitosan conductive layer with a fluorinated dot-line interwoven mesh coating. Such AWAE exhibits exceptional environmental robustness, retaining superhydrophobicity and stable sensing under mechanical abrasion, chemical corrosion (acid/alkali/salt), extreme temperatures, and UV exposure. Notably, the AWAE enables continuous and accurate monitoring of human joint motions, underwater gestures, and robotic operations even in simulated seawater. This work provides a durable and versatile platform for all-weather amphibious sensing, with potential applications in healthcare, marine robotics, and smart underwater wearable systems.