Hydrogel bioadhesives have been extensively applied in wound care, human-machine interfaces, and implantable bioelectronics, owing to their exceptional biocompatibility and adjustable physicochemical attributes. While these adhesives have exhibited clinical efficacy in accelerating wound healing, it remains a significant challenge to simultaneously restore both tissue structure and sensory function in damaged skin using a single material. Herein, we propose an all-natural injectable self-healing multifunctional biomass-based hydrogel bioadhesive using carboxymethyl chitosan (CMCS), sericin (SS), and natural moisturizing factor (NMF) as raw materials, enabling the integrated management of skin bioelectronics and regenerative wound healing. The hydrogel bioadhesive presented remarkable swelling capacity (1094.46%), rapid absorption of tissue exudate, and significant hemostatic efficacy. Meanwhile, the hydrogel bioadhesive displayed high sensitivity to temperature, stress-strain, and bioelectric signals, and could effectively detect various human movements and temperature early warning. Notably, the hydrogel bioadhesive featured a tunable modulus that precisely matched the mechanical properties of skin tissue at wound sites, facilitating near-complete wound healing within 14 days and significantly reducing pro-inflammatory factor levels. Overall, serving as a flexible and durable interface, the hydrogel bioadhesive senses human motion and physiological cues, effectively emulating skin's somatosensory functions. Crucially, it concurrently supports wound healing and multi-signal monitoring in skin bioelectronics.