The mechanism by which contact geometry influences the contact time dependence of adhesion force in layered materials remains unclear, particularly for molybdenum disulfide (MoS 2), which exhibits ultralow friction and a unique layered structure. This study systematically investigates the evolution of interfacial adhesion force at silica-MoS 2 with contact time using atomic force microscopy (AFM) with three distinct cantilever configurations (sharp, spherical and pyramidal cantilever) across a relative humidity (RH) range of 10–90%. The results clearly establish that contact geometry governs the time-dependent adhesion behavior: both pyramidal and spherical cantilevers exhibit clear contact-time-dependent adhesion forces at 10–80% RH, but not at 90% RH. The sharp cantilever exhibits no contact-time-dependent adhesion, as the force rapidly stabilizes and remains constant throughout the 0–200 s contact period. This study was conducted using mechanically exfoliated MoS 2 flakes with a thickness of 50 nm. The preparation process may introduce trace residues of adhesive tape and other exogenous contaminants, yet their influence does not dominate the core evolutionary patterns of the interfacial adhesion forces. These findings provide important insights for mitigating adhesion-related failures in MoS 2-based micro/nano-electro-mechanical systems (M/NEMS).