Previous studies demonstrated the macroscale wear behavior of soda lime silicate (SLS) glass in humid air was governed by the mechanochemical reactivity of sliding interfaces, which is a function of relative humidity (RH). In this study, it was observed that no disenible nanowear of SLS glass surface in dry conditions because the contact is elastic. In humid conditions, nanowear occurred due to water-induced mechanochemical reactions and the RH dependence above 20% was relatively weak. Nanowear of SLS glass decreased at the sodium ions enriched region, which was revealed with ReaxFF-MD simulations. Further analyses revealed that the wear behavior of SLS glass surface depends on both the mechanochemical reactions occurring at the sliding interface and the transport of the mechanochemical reaction products.