In this work, the friction and wear properties of layered MoAlB ceramics sliding against Al2O3 and Inconel 718 alloy (Inc718) from room temperature (RT) to 800 degrees C were studied. The tribological behaviors of MoAlB ceramics are found to be greatly influenced by the test temperature and the counterpart. From RT to 800 degrees C, the MoAlB/Al2O3 tribo-pairs exhibit a higher friction coefficient and wear rate compared with those of the MoAlB/Inc718 tribo-pairs. Irrespective of the laminate structure, the tribological properties of MoAlB ceramics are associated with the oxides that are induced by tribo-oxidation reactions. For the MoAlB/Al2O3 tribo-pairs, abrasive wear and adhesive wear are responsible for the poor friction and wear behaviors. However, the tribofilm, which consists of oxides of Ni, Cr and Fe, can provide a good lubrication effect when MoAlB slides against Inc718.