A systematic investigation has been carried out in the present work to study the electrochemical and corrosion-wear behaviours of Hastelloy C276 alloy sliding against Al2O3 pin in artificial seawater, using a pin-on-disc tribometer integrated with a potentiostat for electrochemical control. It can be observed that the cathodic shift of open circuit potential and three order of magnitude increase of current density formed due to sliding. The total corrosion-wear loss increases with increasing applied potential. Interestingly, the total material loss at the applied potential of 0.5 and 0.9V is more than two times of that of pure mechanical wear, confirming the synergy between wear and corrosion. And, the contributions of wear-induced corrosion (K-c) and corrosion-induced wear (K-w) are dominant, especially at higher applied potentials. Copyright (c) 2015 John Wiley & Sons, Ltd.