Textiles with a freedom of form factor, unlimited scalability, and high programmability provide an ideal platform for constructing wearable optoelectronic systems. The emerging wearable technologies, like artificial intelligence and Internet of Things, have driven the development of textile optoelectronics from simple functional blocks to sophisticated logic systems, offering a seamless, breathable, and programmable on-body platform to synergistically sense, analyze, store, and feedback information in response to complex commands. In the past few years, the creation of such smart textile optoelectronics-based logic systems is boosted by nanomaterial science and manufacturing integration technologies and has revolutionized human–machine interaction paradigms in numerous emerging fields. Herein, in this review, the recent progress of smart textile optoelectronics for human-interfaced logic systems is timely summarized. This review begins with a concise discussion about the wearability evaluation and integration consideration of textile optoelectronic devices. Then, important breakthroughs in human-interfaced logic systems based on smart textile optoelectronics are demonstrated by highlighting their representative device, working principle, and application scenarios. Finally, the existing challenges and potential directions in the field of textile optoelectronics-integrated logic systems are analyzed.