Natural climbers leverage strong friction and minimal adhesion for effective multidirectional movement. Toe pads of species like tree frogs display distinct microstructures with protrusions. Such insights have spurred the formulation of a biomimetic microstructure array for wafer handling applications. The curvature of these protrusions was meticulously analyzed to decipher contact mechanics. Moreover, the intricate balance between strong-friction and weak-adhesion mechanisms was evaluated, considering design variations across surface roughness levels. This culminated in a crafted microstructure array optimized for wafer-handling, highlighting the practicality of bioinspired friction enhancement in contemporary engineering domains.