This article presents new findings related to the assessment of wear test parameters, including material, load, and sliding speed, focusing on understanding the statistical characteristics of response variables such as width, depth, wear volume, specific wear rate, and coefficient of friction. Wet sliding wear tests were conducted on both borided and non-borided AISI 316L-SS samples under controlled environmental conditions. The tests were developed using the ASTM G133-05 standard guidelines and UMT-2 tribological equipment. The results of the variance analysis revealed that the material factor exhibited the most substantial statistical significance for width, depth, wear volume, specific wear rate, and CoF, accounting for 91.4, 88.1, 86.3, 79.4, and 78.8% of the variance, respectively, followed by the normal load factor. The response variables behavior was analyzed through the Surface Response Methodology statistical technique, and the approach equations were obtained.