In order to enhance the hardness and wear resistance of Cr12MoV, Al2CrFeNiMo was designed and successfully prepared by laser cladding. Phase, microstructure, hardness and wear characteristics of the coating were analyzed by x-ray diffractometer, scanning electron microscope, Vickers hardness tester and reciprocating wear tester. The results indicated that the coating was composed of BCC and FCC phases having high lattice distortion and dislocation density. Microstructure of the coating presented the equiaxed grain which was rich in Fe, Cr and existed the segregation of Mo, Al, Ni. The coating demonstrated high hardness, with the values of 600 HV0.2, which was increased by 150% than that of the substrate. Compared with the substrate, the friction coefficient and wear volume of the coating were reduced by 48.9 and 91.32%, respectively. The wear mechanism of the coating was the abrasive wear. However, the substrate exhibited the serious adhesive wear besides the abrasive wear.