Materials with target load plateaus offer the potential for developing innovative vibration suppression and isolation systems for applications such as satellite platforms, submarines, and electric vehicles. However, implementing these materials can pose significant challenges. In this study, stair-stepping mechanical metamaterials with programmable load plateaus are presented, which are created via a three-level (unit, module, and 3D object) construction strategy. The strategy inspired by the inverse design concept achieves tunability in the number and properties of load plateaus within the force–displacement profiles of the metamaterials. This approach even yields appealing stair-stepping response patterns, as validated by experiments and finite element simulations. Promisingly, programming the unit from its initial configuration to a “zero stiffness” configuration enables these metamaterials excellent vibration isolation performance. Furthermore, two reversible methods are proposed for switching among various unit configurations, namely shape memory programming and supporting payload. This innovative design strategy for programmable load plateaus opens up new possibilities for creating metamaterials with customized force–displacement responses. It also provides opportunities to incorporate multimodal vibration isolation capabilities into precision devices.