Liquid-like surfaces (LLSs) with dynamic repellency toward various pollutants (e.g., bacteria, oil, and ice), have shown enormous potential in the fields of biology, environment, and energy. However, most of the reported LLSs cannot meet the demands for practical applications, particularly in terms of de-wettability and durability. To solve these problems, considerable progress has been made in enhancing the de-wettability and durability of LLSs in complex environments. Therefore, this review mainly focuses on the recent progress in LLSs, encompassing designed structures and repellent capabilities, as well as their diverse applications, offering greater insights for the targeted design of desired LLSs. First, a detailed overview of the development of LLSs from the perspective of their molecular structural evolution is provided. Then highlight recent approaches for enhancing the dynamic de-wettability and durability of LLSs by optimizing their structural designs, including linear, looped, crosslinked, and hybrid structures. Later, the diverse applications and unique advantages of recently developed LLSs, including repellency (e.g., liquid anti-adhesion/transportation/condensation, anti-icing/scaling/waxing, and biofouling repellency) are summarized. Finally, Perspectives on potential innovative advancements and the promotion of technology selection to advance this exciting field are offered.