In the last few decades, micro-texturing has become a widely studied technique to modify the frictional behavior between surfaces in both dry and lubricated regimes. Among all the available techniques, the Laser Surface Texturing (LST) appears to be fast, clean and flexible, and thus a good candidate in realizing surface micropatterns, also for the improvement of the tribological performance of automotive components when subjected to dry friction. For this reason, in the present work, the tribological response of four different patterns of micro-holes on two contrasting materials, specifically Silicon Carbide (SiC) and Carbon (C) have been investigated with a coupled experimental-numerical approach. The static and the dynamic friction coefficients have been extracted from the 25 different combinations of these surface textures including the flat counterparts. Then, the influence of the holes diameter, their density and the material has been studied thanks to a multivariate linear regression. Specifically, it emerged that, in a dry regime, the most emerging parameter is the micro-holes diameter, for both static and dynamic friction. Moreover, for both static and dynamic friction, the material which more influences the effects of patterns to the overall frictional behavior is here the stiffest one. These insights for the design of micro-patterned surfaces with controlled frictional properties could be useful for those applications in which a dry friction regime is present.