Friction is ubiquitous in industry and daily life, which not only leads to the wear and tear of equipment and machinery, but also causes a lot of energy waste. Friction is one of the significant factors leading to energy loss in mechanical systems. Therefore, it is essential to minimize friction losses. Creatures in nature have evolved various surfaces with different tribological characteristics to adapt to the environment. By studying, understanding, and summarizing the friction and lubrication regulation phenomena of typical surfaces in nature, various bionic friction regulation theories and methods are obtained to guide the development of new lubrication materials and lubrication systems. This article primarily discusses the study of lubrication mechanisms through biomimetic design, which is mainly divided into chemical approaches, structural strategies, and chemical–structural coupling approaches. From the chemical point of view, this paper mainly summarizes joint lubrication and engineering lubrication in biomedicine, with inspiration from lotus leaves, fish skin, and snake skin, each with unique antifriction structures which are famous for their super hydrophobicity in nature. Finally, chemical–structural coupling simulates the lubrication mechanism of natural organisms from the joint action of biological structures and chemical substances, and is applied to coating design, so as to reduce the friction and wear on coating surfaces, improve the durability and anti-pollution ability of coatings, significantly improve the tribological performance of mechanical systems, promote scientific innovation, and promote energy conservation, emission reduction, and sustainable development.